At a glance: Spacedust is a modular toolkit for identification of conserved gene clusters among multiple genomes based on homology and conservation of gene neighborhood. Spacedust requires a 64-bit system (check with uname -a | grep x86_64) with at least the SSE4.1 instruction set (check by executing cat /proc/cpuinfo | grep sse4_1 on Linux or sysctl -a | grep machdep.cpu.features | grep SSE4.1 on MacOS).