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library(methylKit) data(methylKit) mdb <- makeMethylDB(methylRawList.obj) # works for "base" -resolution unite(mdb,destrand=TRUE) mdb # is fine # breaks for "region" -resolution mdbt <- tileMethylCounts(mdb) mdbt <- methylRawListDB(lapply(mdbt, function(x) {x@resolution <- "base"; x}),treatment = getTreatment(mdb)) # works unite(mdbt) unite(mdbt,destrand=TRUE) > destranding... > Error in getTabixByChunk(tbxFile, chunk.size = nrow, return.type) : > the tabix file seems to be empty. stopping here.
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related to #282
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