You signed in with another tab or window. Reload to refresh your session.You signed out in another tab or window. Reload to refresh your session.You switched accounts on another tab or window. Reload to refresh your session.Dismiss alert
Once METASOFT and/or RE2C have run, we currently match on the coordinate position of each SNP, but we leave out the reference and alternate allele.
This should be included as a priority. It should be easy to include those columns from the VCF when adding the coordinates.
Stretch goal: we should do a sanity check that each cohort has the same reference an alternate allele for each SNP - if a cohort has them the other way round then potentially the direction of effect (beta) would be flipped. This would hurt the meta-analysis considerably.
The text was updated successfully, but these errors were encountered:
Once METASOFT and/or RE2C have run, we currently match on the coordinate position of each SNP, but we leave out the reference and alternate allele.
This should be included as a priority. It should be easy to include those columns from the VCF when adding the coordinates.
Stretch goal: we should do a sanity check that each cohort has the same reference an alternate allele for each SNP - if a cohort has them the other way round then potentially the direction of effect (beta) would be flipped. This would hurt the meta-analysis considerably.
The text was updated successfully, but these errors were encountered: