Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Add alleles to final METASOFT outputs #4

Open
jackhump opened this issue May 24, 2022 · 0 comments
Open

Add alleles to final METASOFT outputs #4

jackhump opened this issue May 24, 2022 · 0 comments
Assignees

Comments

@jackhump
Copy link
Member

Once METASOFT and/or RE2C have run, we currently match on the coordinate position of each SNP, but we leave out the reference and alternate allele.

This should be included as a priority. It should be easy to include those columns from the VCF when adding the coordinates.

Stretch goal: we should do a sanity check that each cohort has the same reference an alternate allele for each SNP - if a cohort has them the other way round then potentially the direction of effect (beta) would be flipped. This would hurt the meta-analysis considerably.

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

3 participants