diff --git a/DESCRIPTION b/DESCRIPTION
index b7fb60b5f..ca4569e1f 100644
--- a/DESCRIPTION
+++ b/DESCRIPTION
@@ -1,6 +1,6 @@
 Package: Seurat
-Version: 4.0.5.9006
-Date: 2021-12-14
+Version: 4.0.6
+Date: 2021-12-16
 Title: Tools for Single Cell Genomics
 Description: A toolkit for quality control, analysis, and exploration of single cell RNA sequencing data. 'Seurat' aims to enable users to identify and interpret sources of heterogeneity from single cell transcriptomic measurements, and to integrate diverse types of single cell data. See Satija R, Farrell J, Gennert D, et al (2015) <doi:10.1038/nbt.3192>, Macosko E, Basu A, Satija R, et al (2015) <doi:10.1016/j.cell.2015.05.002>, Stuart T, Butler A, et al (2019) <doi:10.1016/j.cell.2019.05.031>, and Hao, Hao, et al (2020) <doi:10.1101/2020.10.12.335331> for more details.
 Authors@R: c(
diff --git a/NEWS.md b/NEWS.md
index fa8f7e1b2..2877cc185 100644
--- a/NEWS.md
+++ b/NEWS.md
@@ -1,4 +1,4 @@
-# Unreleased
+# Seurat 4.0.6 (2021-12-16)
 ## Added
 
 - Implement supervised LSI
@@ -11,14 +11,14 @@
 - Add `label.color` parameter to `FeaturePlot` ([#5314](https://github.com/satijalab/seurat/pull/5314))
 - Fix issues in `ProjectUMAP` ([#5257](https://github.com/satijalab/seurat/issues/5257), [#5104](https://github.com/satijalab/seurat/issues/5104), [#5373](https://github.com/satijalab/seurat/issues/5373))
 
-# Seurat 4.0.5 (2020-10-04)
+# Seurat 4.0.5 (2021-10-04)
 ## Changes
 - Update documentation for `to.upper` parameter in `Load10X_Spatial()` ([#4576](https://github.com/satijalab/seurat/issues/4576))
 - Update concept tags for `RunSPCA()` ([#4978](https://github.com/satijalab/seurat/discussions/4987))
 - Conditionally run tests/packages that use suggested packages ([#5160](https://github.com/satijalab/seurat/pull/5160))
 - Set random state in `RunUMAP()` when using the `umap-learn` method ([#5194](https://github.com/satijalab/seurat/issues/5194))
 
-# Seurat 4.0.4 (2020-08-19)
+# Seurat 4.0.4 (2021-08-19)
 ## Added
 - Add `reduction` parameter to `BuildClusterTree()` ([#4598](https://github.com/satijalab/seurat/issues/4598))
 - Add DensMAP option to `RunUMAP()` ([#4630](https://github.com/satijalab/seurat/pull/4630))
diff --git a/cran-comments.md b/cran-comments.md
index 8ae6a6d5b..5799d0411 100644
--- a/cran-comments.md
+++ b/cran-comments.md
@@ -1,7 +1,7 @@
-# Seurat v4.0.5
+# Seurat v4.0.6
 
 ## Test environments
-* local Ubuntu 20.04 install, R 4.1.0
+* local Ubuntu 20.04 install, R 4.1.2
 * Ubuntu 16.04.6 (on travis-ci), R 4.0.0, R devel
 * macOS 10.13.6 (on travis-ci), R 4.0.2
 * Windows Server 2012 R2 (on AppVeyor), R 4.1.0 Patched
@@ -12,8 +12,8 @@ There were no ERRORs, WARNINGs, or NOTEs
 
 ## Downstream dependencies
 
-There is one package that depends on Seurat: tidyseurat; this update does not impact its functionality
+There no packages that depend on Seurat
 
-There are ten packages that import Seurat: CDSeq, DUBStepR, PhitestR, rPanglaoDB, scDiffCom, scMappR, scRNAstat, Signac, SignacX, and SoupX; this update does not impact their functionality
+There are sixteen packages that import Seurat: CAMML, CDSeq, CIDER, DR.SC, DUBStepR, PhitestR, Platypus, rPanglaoDB, scDiffCom, scMappR, SCRIP, scRNAstat, Signac, SignacX, SoupX, and tidyseurat; this update does not impact their functionality
 
 There are ten packages that suggest Seurat: BisqueRNA, ClustAssess, clustree, conos, DIscBIO, dyngen, harmony, rliger, Rmagic, and VAM; this update does not impact their functionality.