diff --git a/samples/peripheral/lpuart/boards/nrf54l15dk_nrf54l15_cpuapp.overlay b/samples/peripheral/lpuart/boards/nrf54l15dk_nrf54l15_cpuapp.overlay
index 2491179217e0..6b6d835c13a3 100644
--- a/samples/peripheral/lpuart/boards/nrf54l15dk_nrf54l15_cpuapp.overlay
+++ b/samples/peripheral/lpuart/boards/nrf54l15dk_nrf54l15_cpuapp.overlay
@@ -34,3 +34,19 @@
 &gpiote20 {
 	status = "okay";
 };
+
+&uart20_default {
+	/* Disconnect CTS and RTS lines from pins.
+	 * This is a workaround for increased current consumption
+	 * (~250 uA more).
+	 */
+	group1 {
+		psels = <NRF_PSEL(UART_TX, 1, 4)>,
+			<NRF_PSEL_DISCONNECTED(UART_RTS)>;
+	};
+	group2 {
+		psels = <NRF_PSEL(UART_RX, 1, 5)>,
+			<NRF_PSEL_DISCONNECTED(UART_CTS)>;
+		bias-pull-up;
+	};
+};