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Bharathi Ramana Joshi
Lectures notes for the Mathematical Models in Biology course, IIIT Hyderbad Monsoon 2021

Lecture 1 : 17/08/2021

  • Model exploits math to represent, analyze or make predictions about real world phenomenon.
  • Models as "replica" of real-life systems.
  • Mathematical models as differential equations.
  • Why need modelling?
    1. Infeasible experiments.
    2. Complicated results that are difficult to comprehend.
  • Uses of models
    • Gives physical explanation of a phenomenon.
    • Helps make predictions.
    • Helps build hypothesis.
  • Biological processes are not static.
  • Dynamical systems: systems changing with times. Examples:
    1. COVID modelling.
    2. Number of predators and preys in ecosystem.
    3. Infections disease modelling.
    4. Gene expansion (transcription, translation).
    5. Signal transduction.
    6. Growth of bacteria in a fermenter.
    7. Sleep cycle.

Differential equations

  • Order of a differential equation = order of highest derivative.
  • Degree of a differential equation = power of highest derivative.
  • Linear differential equation: $$ a_0(x)y^{(n)} + a_1(x)y^{(n - 1)} + \dots + a_n(x)y = F(x) $$

where $a_i(x)$ and $F(x)$ are single variable functions of $x$.

Population models

  • Malthusian model: the rate of growth of population is directly proportional to the population at that moment.
  • Modify Malthusian model to incorporate more complex features.
  • Carrying capacity: limit of a population as time tends to infinity.