author | title |
---|---|
Bharathi Ramana Joshi |
Lectures notes for the Mathematical Models in Biology course, IIIT Hyderbad Monsoon 2021 |
- Model exploits math to represent, analyze or make predictions about real world phenomenon.
- Models as "replica" of real-life systems.
- Mathematical models as differential equations.
- Why need modelling?
- Infeasible experiments.
- Complicated results that are difficult to comprehend.
- Uses of models
- Gives physical explanation of a phenomenon.
- Helps make predictions.
- Helps build hypothesis.
- Biological processes are not static.
- Dynamical systems: systems changing with times. Examples:
- COVID modelling.
- Number of predators and preys in ecosystem.
- Infections disease modelling.
- Gene expansion (transcription, translation).
- Signal transduction.
- Growth of bacteria in a fermenter.
- Sleep cycle.
- Order of a differential equation = order of highest derivative.
- Degree of a differential equation = power of highest derivative.
- Linear differential equation: $$ a_0(x)y^{(n)} + a_1(x)y^{(n - 1)} + \dots + a_n(x)y = F(x) $$
where
- Malthusian model: the rate of growth of population is directly proportional to the population at that moment.
- Modify Malthusian model to incorporate more complex features.
- Carrying capacity: limit of a population as time tends to infinity.