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Chimpanzee centromeres that are acrocentric appear telocentric #143

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eweitz opened this issue Apr 30, 2019 · 0 comments
Open

Chimpanzee centromeres that are acrocentric appear telocentric #143

eweitz opened this issue Apr 30, 2019 · 0 comments

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@eweitz
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eweitz commented Apr 30, 2019

Most chimpanzee centromeres that are acrocentric appear telocentric in Ideogram.js.

Specifically, chimpanzee chromosomes 13, 14, 15, and 22 are acrocentric like their human orthologs, but appear telocentric like mouse chromosomes. The only acrocentric chimpanzee chromosome that is properly rendered as such is chromosome Y.

Below is what the chimpanzee genome looks like in Ideogram.js. Note the centromere positions of chromosomes 13, 14, 15, and 22.
chimpanzee_centromere_position_bug

And here is how chimpanzee looks in NCBI Genome Decoration Page (GDP):
chimpanzee_chromosomes_ncbi_genome_decoration_page

The cause of this issue may be related to Ideogram using Pan_tro_3.0 (panTro5, GCF_000001515.7) as its default chimpanzee genome assembly, whereas the above screenshot of NCBI GDP uses Pan_troglodytes-2.1.4 (panTro4, GCF_000001515.6). GDP has some apparent flaws -- e.g. chr2B is much smaller than shown.

The best available reference for chimpanzee cytogenetics seems to be Yunis, J. & Prakash, O. The origin of man: a chromosomal pictorial legacy. Science 215, 1525–1530 (1982). A figure from that paper shows banded chromosomes of human, chimpanzee, gorilla, and orangutan:

human_chimpanzee_gorilla_and_orangutan_chromosomes__yunis_and_prakesh_1982

Fix this issue with chimpanzee centromere positioning, using NCBI GDP and Yunis and Prakesh (1982) as guidance.

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