Skip to content
New issue

Have a question about this project? Sign up for a free GitHub account to open an issue and contact its maintainers and the community.

By clicking “Sign up for GitHub”, you agree to our terms of service and privacy statement. We’ll occasionally send you account related emails.

Already on GitHub? Sign in to your account

Option for neutral simulations without stop codons #93

Open
ebrintn opened this issue Aug 7, 2024 · 0 comments
Open

Option for neutral simulations without stop codons #93

ebrintn opened this issue Aug 7, 2024 · 0 comments

Comments

@ebrintn
Copy link
Collaborator

ebrintn commented Aug 7, 2024

From @jasondk:

"Okay. I think that's reasonable if modelling pseudogene evolution, but if we are doing neutral simulations of protein coding genes, the suitable model still probably assigns stop codons zero (or close to zero) fitness. Typically codon models simple exclude stop codons from the model entirely, reducing the state space from 64x64 to 61x61 (for standard gen code). I think there are good reasons to do it either way...
It could be useful to have an option to run neutral model with stop codons assigned zero fitnesss. But i think what you've implemented is more general"

Sign up for free to join this conversation on GitHub. Already have an account? Sign in to comment
Labels
None yet
Projects
None yet
Development

No branches or pull requests

1 participant