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GrevillotL edited this page Nov 8, 2017 · 97 revisions

Scope and objectives of the Project:

The OpenGATE collaboration is willing to help clinical users setting-up GATE into the clinics. We are currently about 6 different ion therapy centers using, or about to use, GATE for clinical purposes.

The GATE-RTion project has 3 objectives:

  1. Providing a stable and long term GATE release, called GATE-RTion, having all necessary features for dosimetric applications in Light Ion Beam Therapy facilities equipped with the Pencil Beam Scanning delivery technique.
  2. Providing a collection of tools necessary for the clinical users to interface GATE with the clinical environment
  3. Developing guidelines for clinical users on how to implement GATE into the clinical routine using the provided tools

We plan to release the first version of GATE-RTion by the end of 2017 with all proton functionalities validated. Further releases will include carbon ion functionalities and other features.

List of involved clinical facilities and users

LIBT facility City Country Representatives
MedAustron Wiener Neustadt Austria Loïc Grevillot, Alessio Elia, Antonio Carlino, Hermann Fuchs
Skandion Uppsala Sweden David Boersma, Erik Almhagen
CPO Orsay France Ludovic De Marzi
CAL Nice France Marie Vidal
The Christie Fundation Trust Manchster UK Adam Aitkenhead
UCL / UCLH London UK Andrea Gutierrez, Vasilis Rompokos, Tracy Underwood
CREATIS lab Lyon France David Sarrut

List of GATE functionalities which have been revised for the release 1.0

Configuration: GATEv8.0 (develop branch), GEANT4-10.3, ROOTv6.08.06

Physics-builder: QBBC_EMZ

Functionality Current issue Ticket (GitHub bug tracker) Status Priority Proposals Who? Deadline
TPSPencilBeam source modeling Rotational issues between beam and Couch #84 Done (Pull request #138) 1 Step1. proposal to remove couch rotation from the TPS source, so that TPS-source only account for gantry rotation, as images can be rotated anyhow. Loïc Grevillot Oct. 2017
TPSPencilBeam source modeling Absolute calibration in MU Done (Pull request #138) 1 new feature / code cleaning Loïc Grevillot Oct. 2017
DoseToWater conversion code cleaning for all particles till Protons #104 Done (Pull request #144) 1 To be investigated and fixed Hermann Fuchs Oct. 2017
RangeShifter overlap on CT geometries new (Ludo input) - Done 1 David S. propsoed a new actor David Sarrut Oct. 2017

List of GATE functionalities which should be revised for the release 2.0

Functionality Current issue Ticket (GitHub bug tracker) Status Priority Proposals Who? Deadline
HU to density/composition interpolation issue #37 Open 2 To be investigated and fixed Adam? David B. (with student) TBD
TPSPencilBeam source modeling JASON file implementation Open 2 new feature David Sarrut/David Boersma TBD

List of validation tests required for release 1.0

Test Name Type of test Description Status priority Who? Deadline
TPSPencilBeam source Functional testing (acceptance) Verifying that the spot positions at isocenter and number of particles delivered are as planned; and that the beam optics and energy properties are as set in the source file. Done (Pull request #12 -GateContrib) 1 Loïc Grevillot Oct. 2017
DoseActor Functional testing (acceptance) Verifying that the energy/dose/dose-to-water are scored correctly for non-voxelized and voxelized geometries. Open 1 Hermann Fuchs Oct. 2017
CT modeling Functional testing (acceptance) Verifying the correspondance between HUs and tissue compositions and densities Open 1 Adam? David B. (with student) Dec. 2017
Patient positionning Functional testing (acceptance) Verifying that DICOM image can be adjusted correctly in terms of pitch/roll/jaw and translations x/y/z Open 1 Erik/Marie Dec. 2017
TPS validation workflow with range shifter Functional testing (acceptance) Validation of the TPS plan recalculation workflow based on a treatment plan exported from the TPS and simulated into GATE when the RS geometry overlap with the DICOM image Open 1 Ludovic De Marzi Dec. 2017

List of available Tools

The Open Resources for GATE Monte Carlo simulations (Open-ReGate) platform will be used to share and document all necessary Tools, including guidelines. https://public.kitware.com/open-regate/index.php/Main_Page

Release plan and future developments:

Release plan

The proposed release plan below provides only the main objectives:

  • GATE-RTion V 1.0: all necessary features for dosimetric applications in Light Ion Beam Therapy facilities equipped with the Pencil Beam Scanning delivery technique for Protons + a set of Tools for the user
  • GATE-RTion V2.0: Extension of V1.0 to carbon ion delivery

Future developments

New functionalities provided by the members of the OpenGATE collaboration will be available in the standard GATE release, however they will only be part of a new GATE-RTion release if clinical user interest is raised and common effort agreed with the uses to validate the features. The developments listed below have been identified of potentially interest for the clinical users in future:

  • RBE modeling and implementation of the MKM model (Lydia Maigne)
  • 4D simulations including 4D CT and 4D treatment delivery (David Boersma)

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